Prenatal Exposure to Ketamine Leads to Anxiety-Like Behaviors and Dysfunction in Bed Nucleus of Stria Terminalis

The bed nucleus of the stria terminalis mediates inter-individual variations in anxiety and fear.

While learning to fear stimuli that predict danger promotes survival, the inability to inhibit fear to inappropriate cues leads to a pernicious cycle of avoidance behaviors. Previous studies have revealed large inter-individual variations in fear responding with clinically anxious humans exhibiting a tendency to generalize learned fear to safe stimuli or situations. To shed light on the origin ...

Orbitofrontal cortex lesions alter anxiety-related activity in the primate bed nucleus of stria terminalis.

In children, behavioral inhibition (BI) in response to potential threat predicts the development of anxiety and affective disorders, and primate lesion studies suggest involvement of the orbitofrontal cortex (OFC) in mediating BI. Lesion studies are essential for establishing causality in brain-behavior relationships, but should be interpreted cautiously because the impact of a discrete lesion ...

PS07. Neuronal encoding of anxiety in the bed nucleus of the stria terminalis

s | 3 reinstatement was accompanied by reduction of synaptic input in the IL. Then we hypothesized that prefrontal dopamine plays a key role in reinstatement and tested this idea. A reminder shock induced c-Fos expression in the IL-projecting dopaminergic neurons in the ventral tegmental area. Blocking of IL dopamine D1 receptor signaling prevented reduction of synaptic input, CeM c-Fos express...

The response of neurons in the bed nucleus of the stria terminalis to serotonin: implications for anxiety.

Substantial evidence has suggested that the activity of the bed nucleus of the stria terminalis (BNST) mediates many forms of anxiety-like behavior in human and non-human animals. These data have led many investigators to suggest that abnormal processing within this nucleus may underlie anxiety disorders in humans, and effective anxiety treatments may restore normal BNST functioning. Currently ...

The role of the bed nucleus of the stria terminalis in learning to fear.